HUMAN ANTI TRASTUZUMAB
Product Details
- Cat. No.
- HCA166
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Human
Herceptin® bridging ELISA using Human anti Herceptin® as the coating antibody
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Description
Human anti Trastuzumab antibody, clone AbD16712 a monoclonal antibody recognizes Trastuzumab, also known as Herceptin, is a drug used in the treatment of HER2 positive breast cancer and other HER2 overexpressing cancers including HER2-positive metastatic cancers of the gastrointestinal tract. Herceptin binds to the HER2 (or c-erbB2) proto-oncogene, an EGF receptor-like protein found on 20-30% of breast cancer cells. The binding leads to antibody mediated (complement mediated) killing of the HER2 positive cells.Human anti Trastuzumab (AbD16712) is an anti-idiotypic antibody that specifically recognizes the Herceptin humanised monoclonal antibody and can be used to measure the Heceptin levels in serum from patients.This clone has been demonstrated to inhibit the Herceptin - HER2 interaction. Removal of the preservative is recommended prior to use in functional assays - Bio-Rad recommend the use of a Slide-A-Lyser® dialysis cassette (EQU003) for this purpose.Additional Trastuzumab (Herceptin) specific anti-idiotypic antibodies are available upon request
Biological Information
- Clonality: Monoclonal
- Host: Human
- Isotype: HuCAL Fab monovalent
Handling
- Quantity: 0.1 mg
- Storage: +4ºC, -20ºC if preferred
- Buffer: Phosphate buffered saline, 0.01% Thiomersal
Applications
- ELISA (ELISA)
