Product & ReviewsAntibodies
ICSBP Antibody
Product Details
- Cat. No.
- 252105
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
Interferon regulatory factor 8 (ICSBP) specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). ICSBP plays a negative regulatory role in cells of the immune system. ICSBP is ubiquitinated by TRIM21 in macrophages, a process that is strongly increased upon interferon gamma stimulation. This leads to the enhanced transcriptional activity of target cytokine genes.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Human
- Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human ICSBP.
- Isotype: Rabbit Ig
- Gene: Q02556
Handling
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Western Blotting (WB)