Product & ReviewsAntibodies
IkB-alpha Antibody
Product Details
- Cat. No.
- 251650
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
IkB-alphs (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha) is one member of a family of cellular proteins that function to inhibit the NF-kB transcription factor. IkB-alpha inhibits NF-kB by masking the nuclear localization signals (NLS) of NF-kB proteins and keeping them sequestered in an inactive state in the cytoplasm. In addition, IkB-alpha blocks the ability of NF-kB transcription factors to bind to DNA, which is required for NF-kB's proper functioning. Mutations in the gene encoding IkB-alpha have linked to Hodgkin's lymphoma.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Human, Mouse, Rat
- Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human IkB-alpha.
- Isotype: Rabbit Ig
- Gene: P25963
Handling
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Immunohistochemistry (IHC)
- Western Blotting (WB)