IKBKB Antibody
Product Details
- Cat. No.
- 252687
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
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Description
IKBKB (Inhibitor of kappa light polypeptide gene enhancer in B-cells kinase beta, also called IKK2/IKKB) is a member of the IKK complex which is composed of IKK-alpha, IKK-beta, IKK-gamma and IKAP. Phosphorylation of I-Kappa-B on a serine residue by the IKK complex frees NF-kB from I-Kappa-B and marks it for degradation via ubiquination. IKK-beta has been shown to activate NF-kB and phosphorylate IKB-alpha and beta. Phosphorylation of 2 sites at the activation loop of IKK-beta is essential for activation of IKK by TNF and IL1. Once activated, IKK-beta is autophosphorylated which in turn decreases IKK activity and prevents prolonged activation of the inflammatory response. Additionally, IKK-beta activity can also be regulated by MEKK-1.
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human
- Antigen: Purified recombinant fragment of IKBKB expressed in E. coli.
- Isotype: Mouse IgG1
- Gene: O14920
Handling
- Quantity: 0.1 ml
- Storage: Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Applications
- Western Blotting (WB)