Product & ReviewsAntibodies

IL-33 (12H6D12) Antibody

Product Details

Cat. No.
253277
Type
Primary Antibody
Clonality
Monoclonal
Host
Mouse
Abbiotec

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Description

Interleukin-33 (IL-33) is a recently identified member of the IL-1 family of cytokines whose other members include IL-1a, IL-1b, IL-1Ra and IL-18. The IL-33 receptor has been shown to be ST2, an IL-1 receptor family member that also acts as a negative regulator of TLR-IL-1R signaling and IL-1R accessory protein (IL-1RAcP). Receptor binding of IL-33 activates NF-kappa B and MAP kinases and induces the expression of TH2-associated cytokines such as IL-4, IL-5 and IL-6. Prolonged IL-33 treatment of mice led to the development of eosinophilia, splenomegaly, and severe pathological changes in mucosal organs such as lungs, esophagus and small intestine. Recent experiments have shown that IL-33 can also co-localize with heterochromatin and possesses transcriptional repressor activities, indicating that IL-33 may function as both a proinflammatory cytokine and an intracellular nuclear factor with transcriptional regulatory properties. Despite its predicted molecular weight, IL-33 will often run at higher molecular weight in SDS-PAGE.

Biological Information

  • Clonality: Monoclonal
  • Host: Mouse
  • Reactivity: Human, Mouse
  • Antigen: Recombinant IL-33 protein.
  • Clone: 12H6D12
  • Isotype: mouse IgG1
  • Gene: NP_254274

Handling

  • Quantity: 0.1 mg
  • Storage: Store at 4°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.

Applications

  • ELISA (ELISA)
  • Immunohistochemistry (IHC)
  • Western Blotting (WB)
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