IL-6R Antibody
Product Details
- Cat. No.
- 252201
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
Interleukin-6R binds to IL6 with low affinity, but does not transduce a signal. A soluble IL-6R is produced by both naive and memory CD4 T cells upon TCR activation. The production of IL6-R by activated CD4 T cells is mediated by shedding of the membrane-bound IL-6R, and this process correlates with the expression of the metalloproteinase ADAM17 in these cells. In contrast to CD4 T cells, CD8 T cells do not express ADAM17 and their production of IL-6R is negligible. Thus, during an immune response CD4 T cells are an important source of IL-6R. Production of IL-6R by autoreactive CD4 T cells may contribute to their role in the development of autoimmune disease by conferring IL-6-responsiveness to cells lacking IL-6R such as synoviocytes.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Human
- Antigen: KLH-conjugated synthetic peptide encompassing a sequence within human IL-6R.
- Isotype: Rabbit Ig
- Gene: P08887
Handling
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Immunohistochemistry (IHC)
- Western Blotting (WB)