Product & ReviewsAntibodies
Insulin Receptor-beta Antibody
Product Details
- Cat. No.
- 250724
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
Insulin Receptor-beta (INSR) binds insulin and has a tyrosine protein kinase activity. The short isoform has a higher affinity for insulin. The receptor mediates the metabolic functions of insulin. Receptor binding to insulin stimulates association of the receptor with downstream mediators including IRS1 and phosphatidylinositol 3'-kinase (PI3K). Defects in INSR are the cause of insulin resistance.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Human, Mouse, Rat
- Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human insulin receptor-beta.
- Isotype: Rabbit Ig
- Gene: P06213
Handling
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Immunohistochemistry (IHC)
- Western Blotting (WB)