Product & ReviewsAntibodies
Integrin beta-2 Antibody
Product Details
- Cat. No.
- 251165
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
CD18 Integrin beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. CD18 Integrin beta-2 is a receptor for the iC3b fragment of the third complement component and for fibrinogen. CD18 Integrin beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain, binds P1 and P2 peptides of fibrinogen gamma chain, and is also a receptor for factor X. Defects in CD18 Integrin beta-2 are the cause of leukocyte adhesion deficiency type 1 (LAD1). LAD1 patients have recurrent bacterial infections and their leukocytes are deficient in a wide range of adhesion-dependent functions.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Human, Mouse, Rat
- Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human Integrin beta-2.
- Isotype: Rabbit Ig
- Gene: P05107
Handling
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Immunohistochemistry (IHC)
- Western Blotting (WB)