KLHL13 (8D1) Antibody
Product Details
- Cat. No.
- 253027
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
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Description
KLHL13 (Kelch-like protein 13) is a 604 amino acid long protein that contains six Kelch repeats and one BTB/POZ domain. Expressed predominantly in brain, KLHL13 is believed to play a role in protein ubiquitination and may function as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex. E3 ligases accept a ubiquitin residue from an E2 ubiquitin-conjugating enzyme and immediately transfer that residue to a protein that is targeted for degradation. Specifically, KLHL13 interacts with KLHL9 and CUL-3, a member of the cullin family of mediators that participate in the selective targeting of proteins for ubiquitin-mediated proteolysis. Via its BTB and C-terminal Kelch (BACK) motif, KLHL13 is thought to play a role in spatially orientating substrates in the CUL-3 ligase.
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human
- Antigen: Purified recombinant fragment of human KLHL13 expressed in E. coli.
- Clone: 8D1
- Isotype: Mouse IgG1
- Gene: Q9P2N7
Handling
- Quantity: 0.1 ml
- Storage: Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Applications
- ELISA (ELISA)
- Flow Cytometry (FC)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blotting (WB)