Product & ReviewsAntibodies
KLHL21 (2H4) Antibody
Product Details
- Cat. No.
- 253023
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
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Description
KLHL21 (Kelch-like protein 21) protein is part of the ubiquitin-proteasome pathway. It is a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR (KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome.
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human
- Antigen: "Purified recombinant fragment of human KLHL21 expressed in E. coli. <br>"
- Clone: 2H4
- Isotype: Mouse IgG1
- Gene: Q9UJP4
Handling
- Quantity: 0.1 ml
- Storage: Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Applications
- Immunohistochemistry (IHC)
- Western Blotting (WB)