[KO Validated] Caspase-3 Rabbit pAb
Product Details
- Cat. No.
- A2156
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
Western blot - Caspase-3 antibody (A2156)
The supplier does not provide quotations for this antibody through SelectScience. You can search for similar antibodies in our Antibody Directory.
Description
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Human, Mouse, Rat
Handling
- Specificity: 4.5
Applications
Antibody works well.
Western blot
This antibody works well in detecting uncleaved version of casepase-3, though cannot detect cleaved version of the protein, use at 1:500 for primary dilution.
Review Date: 22 Jun 2021 | ABclonal Technology
Excellent antibody.
Immunoblot
High quality, clear western blot bands. Antibody is very specific and sensitive. 1:1000 dilution would be enough.
Review Date: 30 Jul 2020 | ABclonal Technology
