[KO Validated] MANF Rabbit pAb
Product Details
- Cat. No.
- A13371
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
Western blot - MANF Antibody (A13371)
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Description
The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and results in cell proliferation. Activity of this protein is important in promoting the survival of dopaminergic neurons. The presence of polymorphisms in the N-terminal arginine-rich region, including a specific mutation that changes an ATG start codon to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus no longer thought to be tumor-related.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Human
