KSHV ORF45 (2D4A) Antibody
Product Details
- Cat. No.
- 252608
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
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Description
KSHV (Kaposi's sarcoma-associated herpesvirus) belongs to the gamma-2 herpesvirus subfamily and has been closely linked to the Kaposi’s sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman’s disease. The genome of KSHV is 165-170 kb and contains at least 88 open reading frames. ORF45 protein encoded by an immediate-early gene in the KSHV genome is characterized as a phosphorylated protein and it is localized in the cytoplasm of infected cells. Studies have shown that ORF45 Protein interacted with cellular IRF-7 and blocked virus-mediated phosphorylation and nuclear translocation of IRF-7. In consequence, ORF45 efficiently inhibited virus-induced production of type I IFN. It was reported that the ORF45 protein was associated with purified virions.
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Virus
- Antigen: Purified recombinant fragment of KSHV ORF45 expressed in E. coli.
- Clone: 2D4A5
- Isotype: Mouse IgG1
- Gene: F5HDE4
Handling
- Quantity: 0.1 ml
- Storage: Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Applications
- Immunocytochemistry (ICC)
- Western Blotting (WB)