Product & ReviewsAntibodies

Lamin B2 Monoclonal Antibody (E-3)

Product Details

Cat. No.
33-2100
Type
Primary Antibody
Clonality
Monoclonal
Host
Mouse
Thermo Fisher Scientific

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Description

Nuclear lamins form a network of intermediate-type filaments at the nucleoplasmic site of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished, i.e. A-type lamins and B-type lamins. The A-type lamins comprise a set of three proteins arising from the same gene by alternative splicing, i.e. lamin A, lamin C and lamin Adel 10, while the B-type lamins include two proteins arising from two distinct genes, i.e. lamin B1 and lamin B2. Recent evidence has revealed that mutations in A-type lamins give rise to a range of rare but dominant genetic disorders, including Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy with conduction-system disease and Dunnigan-type familial partial lipodystrophy. In addition, the expression of A-type lamins coincides with cell differentiation and as A-type lamins specifically interact with chromatin, a role in the regulation of differential gene expression has been suggested for A-type lamins. For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Biological Information

  • Clonality: Monoclonal
  • Host: Mouse
  • Reactivity: Chicken, Human, Mouse, Rat
  • Isotype: IgG1, kappa

Handling

  • Quantity: 100 µg
  • Storage: Store at -20°C
  • Buffer: PBS, pH 7.4
  • Specificity: 4

Applications

  • Immunocytochemistry (ICC)
  • Immunofluorescence (IF)
  • Immunohistochemistry (IHC)
  • Immunohistochemistry (Paraffin-Embedded Sections) (IHC (P))
  • Immunoprecipitation (IP)
  • Western Blotting (WB)

Average Rating 4.3

|1Scientists have reviewed this product

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Another reliable standard to develop a quality image.

 

Average Rating 4.3

Application Area:

Immuno-staining

This antibody gives a characteristic signal, post development!

Review Date: 3 Mar 2021 | Thermo Fisher Scientific

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