Lck (8E5F) Antibody
Product Details
- Cat. No.
- 252663
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
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Description
Lck (Lymphocyte-specific protein tyrosine kinase) is a 509-amino acid protein (~56kDa), belongs to the Src non-receptor tyrosine kinases family. The Src family is composed of nine members in vertebrates, including Src, Yes, Fgr, Frk, Fyn, Lyn, Hck, Lck and Blk. Lck is expressed predominantly in T cells and is localized to the inner surface of the plasma membrane. Lck is activated after T cell stimulation and is required for T-cell proliferation and IL-2 production. Aberrant expression or activation of Lck kinase has been reported in both lymphoid and nonlymphoid malignancies. Inhibition of Lck has been a target to prevent lymphocyte activation and acute rejection.
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human
- Antigen: Purified recombinant fragment of human Lck expressed in E. coli.
- Clone: 8E5F9, 4B2C7
- Isotype: Mouse IgG2a
- Gene: Q9UQQ2
Handling
- Quantity: 0.1 ml
- Storage: Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Applications
- Western Blotting (WB)