MAD2L1 mouse antibody (mAb) (Clone 17D10)
Product Details
- Cat. No.
- 39399
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
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Description
The MAD2L1 (MAD2-like 1 gene is the human homologue of the budding yeast MAD2 - mitotic arrest deficient 2 - gene) protein is a component of the mitotic spindle assembly checkpoint, which monitors the attachment of the mitotic spindle to the kinetochores of segregating chromosomes and delays the onset of anaphase until the process is complete and the chromosomes are properly aligned on the metaphase plate. MAD2L1 associates only with unattached kinetochores in prometaphase, and prevents cell cycle progression by associating with the Anaphase Promoting Complex (APC), specifically restricting the activity of the CDC20 protein.
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Not Species Specific, Human, Mouse
- Clone: 17D10
- Isotype: IgG1
Handling
- Quantity: 200 ug
- Storage: Antibodies in solution can be stored at -20C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
Applications
- Western Blotting (WB)