Magic™ Anti-MCM2 (Phospho S41) polyclonal antibody
Product Details
- Cat. No.
- CPBT-67795RH
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
Rabbit Anti-Human MCM2 (Phospho S41) polyclonal antibody for WB. This product specifically recognises the nuclear protein MCM2 (mini chromosome maintenance protein 2), when phosphorylated at Ser41. MCM2 is a putative DNA replicative helicase and member of the MCM family, critical during the initiation of DNA replication. During the G1 phase of the cell cycle the MCM proteins, part of the pre-replicative complex which assembles at replication origins, undergo phosphorylation by kinases including cyclin dependent kinase (CDK) and Cdc7/Dbf4 (DDK). Studies have shown that the phosphorylation of MCM2 occurs on multiple sites, namely Ser27, Ser41, Ser53, Ser108 and Ser139 and that phosphorylation results in a conformational change of the complex and activation of the helicase activity. Western Blotting detects a band of approximately 120-130kDa in HeLa cell lysates. Applications：WB
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Human
- Conjugate: Unconjugated
- Isotype: Polyclonal IgG
- Gene: 4171
Handling
- Quantity: 50 μg
- Storage: in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Applications
- Flow Cytometry (FC)