Magic™ Anti-NMDA receptor (Phospho S1480) polyclonal antibody

Rabbit Anti-Rat NMDA receptor (Phospho S1480) polyclonal antibody for WB. This product specifically recognises the 180kDa NR2B subunit of the NMDA (N-methyl- D-aspartate) receptor, when phosphorylated at Ser1480. Receptors for NMDA belong to a group of ionotropic glutamate receptors which play a key role in the mediation of glutamate neurotransmission within the mammalian central nervous system (CNS), including involvement in memory and learning processes. Several antagonists and agonists of NMDA receptors (NMDAR) have been identified, including the glutamate analogue homoquinolinic acid, which displays a higher affinity for NR2B-containing NMDAR. Properties of NMDAR include modulation by glycine, inhibition by Zn2+, voltage-dependent Mg2+ blockade and high Ca2+permeability. Studies have shown that the phosphorylation of the Ser1480 site within the C-terminal PDZ ligand of the NR2B subunit of NMDAR, by casein kinase II (CK2), results in a decrease in neuron NR2B surface expression. The involvement of NMDAR in the CNS has become a focus area for neurodegenerative diseases such as Alzheimer's disease and also epilepsy and ischemic neuronal cell death. Western Blotting detects a band of approximately 180kDa in rat hippocampal cell lysates. Applications：WB

• Clonality: Polyclonal
• Host: Rabbit
• Reactivity: Bovine, Chicken, Dog (Canine), Human, Mouse, Primate, Rat, Zebrafish
• Conjugate: Unconjugated
• Isotype: Polyclonal IgG
• Gene: 24410

• Quantity: 100 μl
• Storage: in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.

• Flow Cytometry (FC)