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Human Anti-Human PGR (Phospho S190) monoclonal antibody for IHC-Fr; IHC-P; WB. This product is specific for both the PR-A and PR-B isoforms of human progesterone receptor, when phosphorylated at serine 190. Progesterone receptor (PR) is a member of the steroid hormone receptor superfamily, and is expressed in a range of tissues, including ovary, endometrium, uterus and placenta, and may play a key role in the regulation and differentiation of mammary glands, The detection of estrogen (ER) and progesterone (PR) receptors using immunohistochemical staining , has gradually replaced ligand binding assays (LBA), to become the most common method for the determination of the ER/PR status of breast tumors. Approximately 75% to 80% of breast tumors have estrogen and/or progesterone receptors, and the presence of these receptors helps determine both the patient's prognosis and the effectiveness of hormonal therapy. Western Blotting recognises bands of approximately 90kDa and 120kDa in whole cell T47D lysates, corresponding to phospho PR-A and PR-B respectively. Applications：IHC-Fr; IHC-P; WB