Magic™ Anti-progesterone receptor (Phospho S294) monoclonal antibody, clone 608

Mouse Anti-Human progesterone receptor (Phospho S294) monoclonal antibody for IHC-Fr; WB. This product is specific for both the PR-A and PR-B isoforms of human progesterone receptor, when phosphorylated at serine 294. Progesterone receptor (PR) is a member of the steroid hormone receptor superfamily, and is expressed in a range of tissues, including ovary, endometrium, uterus and placenta, and may play a key role in the regulation and differentiation of mammary glands, The detection of estrogen (ER) and progesterone (PR) receptors using immunohistochemical staining , has gradually replaced ligand binding assays (LBA), to become the most common method for the determination of the ER/PR status of breast tumors. Approximately 75% to 80% of breast tumors have estrogen and/or progesterone receptors, and the presence of these receptors helps determine both the patient's prognosis and the effectiveness of hormonal therapy. Western Blotting * For the detection of phosphoproteins, serine phosphatase inhibitors such as 10mM Sodium Fluoride should be added to the sample buffer. Milk or other casein-based blocking solutions are not recommended as casein is a phosphoprotein and its use can result in high background. Applications：IHC-Fr; WB

• Clonality: Monoclonal
• Host: Mouse
• Reactivity: Human, Monkey, Mouse, Rat
• Conjugate: Unconjugated
• Isotype: IgG1
• Gene: 5241

• Quantity: 100 μl
• Storage: in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.

• Flow Cytometry (FC)