Magic™ Anti-TPH2 (Phospho S19) polyclonal antibody
Product Details
- Cat. No.
- CPBT-66759RR
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
Rabbit Anti-Rat TPH2 (Phospho S19) polyclonal antibody for WB. This product specifically recognises the 55kDa Tryptophan Hydroxylase 2 (TPH2) protein, when phosphorylated at Ser19. Tryptophan Hydroxylase (TPH) is a rate-limiting enzyme which catalyses the 5-hydroxylation of tryptophan, to form the amino acid 5-hydroxytryptophan (5-HTP), in the first stage of the biosynthesis of the neurotransmitter serotonin (5-hydroxytryptamine/5HT). Mammalian TPH is encoded by two genes: TPH1 expressed in peripheral tissues e.g. skin and gut, and TPH2 primarily expressed in the brain. Studies have demonstrated the regulation/enhancement of TPH activity through phosphorylation by cAMP?dependent protein kinase (PKA) and Ca2+/calmodulin kinase II (CaMKII), the latter of which phosphorylates a Ser19 site within the regulatory domain of TPH2. Western Blotting detects a band of approximately 55kDa on lysates from human dorsal Raphe nucleus. Applications：WB
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Bovine, Human, Mouse, Rat, Zebrafish
- Conjugate: Unconjugated
- Isotype: Polyclonal IgG
- Gene: 317675
Handling
- Quantity: 100 μl
- Storage: in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Applications
- FLISA (FLISA)
- Flow Cytometry (FC)
- Immunohistochemistry (IHC)