Magic™ Anti-Y Hydroxylase (Phospho S19) polyclonal antibody
Product Details
- Cat. No.
- CPBT-66686RT
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
Rabbit Anti-Human Y Hydroxylase (Phospho S19) polyclonal antibody for IHC-Fr; IF; WB. This product is specific for Tyrosine Hydroxylase, when phosphorylated at serine 19. Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in the biosynthetic pathway of the catecholamines dopamine (DA), norepinephrine, and epinephrine. The enzyme exists as a tetramer, with each subunit composed of an N-terminal regulatory domain and a C-terminal catalytic domain. Phosphorylation of TH has been shown to occur at several serine residues. Phosphorylation at serine 40 results in an increase in hydroxylase activity, and phosphorylation at serine 19 is reported to promote phosphorylation of the serine 40 residue. Tyrosine hydroxylase is regularly used as a marker for dopaminergic neurons, which is particularly relevant for research into Parkinson's disease. Western Blotting detects a band of approximately 60kDa in stimulated PC-12 cell lysates. Applications：IHC-Fr; IF; WB
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Human, Mouse, Rat
- Conjugate: Unconjugated
- Isotype: Polyclonal IgG
- Gene: 7054
Handling
- Quantity: 100 μl
- Storage: in frost-free freezers is not recommended. This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.
Applications
- Flow Cytometry (FC)