MAN2B1 Rabbit pAb
Product Details
- Cat. No.
- A9937
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
Western blot - MAN2B1 antibody (A9937)
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Description
This gene encodes an enzyme that hydrolyzes terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. Its activity is necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover and it is member of family 38 of glycosyl hydrolases. The full length protein is processed in two steps. First, a 49 aa leader sequence is cleaved off and the remainder of the protein is processed into 3 peptides of 70 kDa, 42 kDa (D) and 13/15 kDa (E). Next, the 70 kDa peptide is further processed into three peptides (A, B and C). The A, B and C peptides are disulfide-linked. Defects in this gene have been associated with lysosomal alpha-mannosidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Mouse
