Product & ReviewsAntibodies

MD-2 (9F1B1) Antibody

Product Details

Cat. No.
253270
Type
Primary Antibody
Clonality
Monoclonal
Host
Mouse
Abbiotec

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Description

MD-2 is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs). TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses. TLR4, the major signaling receptor for lipopolysaccharide (LPS), requires the binding of MD-2 to its extracellular region for maximal response to LPS. The specificity of this response is determined by the species of MD-2; e.g., human MD-2 transfected into mouse cells can cause mouse TLR4 to react to LPS analogs that are normally antagonistic to human but not mouse TLR4.

Biological Information

  • Clonality: Monoclonal
  • Host: Mouse
  • Reactivity: Human, Mouse
  • Antigen: Amino acids 2 to 160 of human MD-2
  • Clone: 9F1B1
  • Isotype: mouse IgG1
  • Gene: NP_056179

Handling

  • Quantity: 0.1 mg
  • Storage: Store at 4°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.

Applications

  • ELISA (ELISA)
  • Immunohistochemistry (IHC)
  • Western Blotting (WB)
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