Product & ReviewsAntibodies

MEK1/2 (Ser218/222) Antibody

Product Details

Cat. No.
252554
Type
Primary Antibody
Clonality
Polyclonal
Host
Rabbit
Abbiotec

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Description

Dual specificity mitogen-activated protein kinase kinase 1 (MEK1/2) catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. MEK1/2 activates ERK1 and ERK2 MAP kinases. Defects in MEK1/2 are a cause of cardiofaciocutaneous syndrome (CFC syndrome), also known as cardio-facio-cutaneous syndrome. CFC syndrome is characterized by distinctive facial appearance, heart defects and mental retardation.

Biological Information

  • Clonality: Polyclonal
  • Host: Rabbit
  • Reactivity: Bovine, Chicken, Dog (Canine), Human, Rat, Xenopus, Zebrafish
  • Antigen: KLH-conjugated synthetic phosphopeptide encompassing a sequence surrounding Ser218/222 of human MEK1/2.
  • Isotype: Rabbit Ig
  • Modifications: Phosphospecific Antibody
  • Gene: Q02750

Handling

  • Quantity: 0.1 ml
  • Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.

Applications

  • ELISA (ELISA)
  • Western Blotting (WB)
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