Product & ReviewsAntibodies

MEK1 (Thr292) Antibody

Product Details

Cat. No.
252555
Type
Primary Antibody
Clonality
Polyclonal
Host
Rabbit
Abbiotec

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Description

MEK1 (MAPKK1) catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. MEKI (MAPKK1) activates ERK1 and ERK2 MAP kinases, enzymes which are involved in numerous signal transduction pathways. Defects in MEK1 (MAPKK1) are a cause of cardiofaciocutaneous syndrome (CFC syndrome), also known as cardio-facio-cutaneous syndrome. CFC syndrome is characterized by a distinctive facial appearance, heart defects and mental retardation. The sites on MEK 1 that are phosphorylated by MAP kinase are Thr292 and Thr386.

Biological Information

  • Clonality: Polyclonal
  • Host: Rabbit
  • Reactivity: Bovine, Dog (Canine), Human, Mouse, Rat
  • Antigen: KLH-conjugated synthetic phosphopeptide encompassing a sequence surrounding Thr292 of human MEK1.
  • Isotype: Rabbit Ig
  • Modifications: Phosphospecific Antibody
  • Gene: Q02750

Handling

  • Quantity: 0.1 ml
  • Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.

Applications

  • ELISA (ELISA)
  • Western Blotting (WB)
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