Metadherin (2F11) Antibody
Product Details
- Cat. No.
- 252933
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
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Description
Metadherin (Metastasis adhesion protein) localizes with the tight junction proteins ZO-1 and occludin in polarized epithelial cells. At the tight junction, it acts not as a structural component, but is rather recruited during the maturation of the tight junction complex. Metadherin is overexpressed in breast cancer tissue and breast tumor xenografts, while much lower levels are expressed in normal breast tissue. Metadherin binds to lung vasculature, one of the four common sites of breast cancer metastasis, through a C-terminal segment in the extracellular domain; blocking this lung-homing domain with antibodies or inhibiting metadherin with siRNA has been reported to inhibit breast cancer metastasis.
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human
- Antigen: Purified recombinant fragment of human MTDH expressed in E. coli.
- Clone: 2F11C3
- Isotype: Mouse IgG1
- Gene: Q86UE4
Handling
- Quantity: 0.1 ml
- Storage: Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Applications
- Flow Cytometry (FC)
- Immunohistochemistry (IHC)
- Western Blotting (WB)