Product & ReviewsAntibodies
MIP-1-beta Antibody
Product Details
- Cat. No.
- 251417
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
Macrophage inflammatory protein 1-beta (MIP1-beta) is a monokine with inflammatory and chemokinetic properties. MIP-1 binds to CCR5, one of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Human, Mouse, Rat
- Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human MIP-1-beta.
- Isotype: Rabbit Ig
- Gene: P13236
Handling
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Immunohistochemistry (IHC)
- Western Blotting (WB)