Product & ReviewsAntibodies

MLL / HRX mouse antibody (mAb) (Clone N4.4), sample

Product Details

Cat. No.
39830
Type
Primary Antibody
Clonality
Monoclonal
Host
Mouse
Active Motif

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Description

MLL1 (Mixed-lineage leukemia protein 1, KMT2A, TRX1, HRX1, ALL1) is a SET-domain containing histone methyltransferase specific for lysine 4 of of histone H3. It serves as a transcriptional activator for many target genes, including several HOX genes. MLL is a frequent target for translocations in acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL) and mixed lineage leukemia (MLL). A key feature of MLL fusion proteins is their ability to efficiently transform hematopoietic cells into leukemia stem cells. Leukemogenic MLL translocations encode MLL fusion proteins that have lost H3 Lys4 methyltransferase activity. MLL1 is found in a complex of proteins that includes ASH2L, WDR5, DPY30 and RBBP5.

Biological Information

  • Clonality: Monoclonal
  • Host: Mouse
  • Reactivity: Human, Mouse
  • Clone: N4.4
  • Isotype: IgG1

Handling

  • Quantity: 10 ug
  • Storage: Antibodies in solution can be stored at -20C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Applications

  • Chromatin Immunoprecipitation (ChIP)
  • Immunoprecipitation (IP)
  • Western Blotting (WB)
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