Product & ReviewsAntibodies

MOUSE ANTI CHICKEN CD45

Product Details

Cat. No.
MCA2413GA
Type
Primary Antibody
Clonality
Monoclonal
Host
Mouse
Buy Now
Bio-Rad

Receive your quote directly from the manufacturer.

Description

Mouse anti Chicken CD45 antibody, clone UM16-6 recognizes chicken CD45, also known as leucocyte common antigen. CD45 is a heavily-glycosylated transmembrane protein tyrosine phosphatase (PTPase) expressed by all nucleated cells of haematopoietic origin. Variation in the expression of a particular CD45 isoform, is regulated during the haematopoietic development of the different cell lineages. CD45 is essential for antigen-induced signal transduction through the antigen receptor and as with other PTPase family members, acts in balance with protein tyrosine kinases, causing the dephosphorylation of negative regulatory tyrosine sites. Studies have indicated that dephosphorylation by CD45, is required for the activation of the src-family kinases p56lck and p59fyn.Investigations into the properties of CD45 in chicken models are limited, but there is evidence of the existence of an additional cysteine residue near the transmembrane region. The overall domain structure between mammalian and chicken CD45 appears to be conserved, but the sequence homology between the extracellular regions is very low.

Biological Information

  • Clonality: Monoclonal
  • Host: Mouse
  • Reactivity: Chicken
  • Isotype: IgG2a

Handling

  • Quantity: 0.1 mg
  • Storage: +4ºC, -20ºC if preferred
  • Buffer: Phosphate buffered saline, 0.09% Sodium Azide

Applications

  • Flow Cytometry (FC)
  • Immunohistochemistry (Frozen Sections) (IHC (Fr))
  • Immunoprecipitation (IP)
Specificity rating
Sensitivity rating
Quality rating
Write your own review

Product Overview

Links