Product & ReviewsAntibodies

MOUSE ANTI EGF RECEPTOR (pTyr1068)

Product Details

Cat. No.
VMA00749
Type
Primary Antibody
Clonality
Monoclonal
Host
Mouse
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Bio-Rad

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Description

Mouse anti Human EGF receptor antibody recognizes the epidermal growth factor receptor, also known as proto-oncogene c-ErbB-1 or receptor tyrosine-protein kinase erbB-1, when phosphorylated at tyrosine 1068. EGF R plays a role in numerous cellular processes such as cell proliferation and apoptosis through the activation of downstream signaling pathways (Scaltriti and Baselga 2006). EGF R is autophosphorylated at tyrosine 1068 upon ligand binding and receptor dimerization (Downward et al. 1984; Bishayee et al. 1999).Phosphorylation of this residue is required for binding of Grb2 adaptor protein (Yamauchi et al. 1997).

Biological Information

  • Clonality: Monoclonal
  • Host: Mouse
  • Reactivity: Human
  • Isotype: IgG1

Handling

  • Quantity: 100 µl
  • Storage: -20ºC only
  • Buffer: Phosphate buffered saline, 0.09% Sodium Azide, PEG, Sucrose

Applications

  • Western Blotting (WB)
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