MOUSE ANTI GROWTH CONE

Mouse anti Growth Cone antibody, clone 2G13 recognizes a protein originally termed 2G13P which is localized to growth cones. Subsequent investigation has identified this protein to be 40S ribosomal protein SA, also known as 37 kDa laminin receptor precursor or Laminin receptor 1 (Baloui et al. 2004). 40S ribosomal protein SA is a 296 amino acid ~37 kDa membrane, cytoplasmic and nuclear protein required for the assembly and/or stability of the 40S ribosomal subunit.. In vertebrate evolution the molecule has acquired a secondary function as a laminin receptor (UniProt: P50890). In growth cones expression is notable particularly in filopodia and lamellipodia in developing rat CNS and embryonic neurons in culture (Stettler et al. 1999).40S ribosomal protein SA interacts with the filamentous actin cytoskeleton and therefore may be involved in growth cone motility (Stettler et al. 1999). Mouse anti Growth Cone antibody, clone 2G13 has been used for the detection of growth cones by immunohistochemistry and identification of 40S ribosomal protein SA by western blotting in chicken and rat samples (Baloui et al. 2004).

• Clonality: Monoclonal
• Host: Mouse
• Reactivity: Chicken, Mouse, Rat
• Isotype: IgM

• Quantity: 2 ml
• Storage: +4ºC, -20ºC if preferred
• Buffer: 0.09% Sodium Azide

• Immunohistochemistry (Frozen Sections) (IHC (Fr))
• Immunohistochemistry (Paraffin-Embedded Sections) (IHC (P))