MOUSE ANTI GSK3 ALPHA (pSer21)
Product Details
- Cat. No.
- VMA00754
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
Western Blot analysis of HepG2 untreated and PVD treated whole cell lysates
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Description
Mouse anti GSK3 alpha antibody recognizes glycogen synthase kinase-3 alpha, also known as serine/threonine-protein kinase GSK3A, when phosphorylated at serine 21. GSK3 controls several physiological processes, such as modulation of transcription factor AP-1 (Nikolakaki et al. 1993) and CREB (Fiol et al. 1994) as well as glycogen metabolism (Welsh and Proud 1993). The kinase has also been reported to regulate cyclin D1 proteolysis and localization (Diehl et al. 1998). Phosphorylation of GSK3 at serine 21 leads to inactivation of the kinase (Frame et al. 2001) and is associated with poor survival chances in Acute Myeloid Leukemia (AML) patients (Ruvolo et al. 2015).
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human
- Isotype: IgG1
Handling
- Quantity: 100 µl
- Storage: -20ºC only
- Buffer: Phosphate buffered saline, 0.09% Sodium Azide, PEG, Sucrose
Applications
- Western Blotting (WB)
