MOUSE ANTI HUMAN BAX (N-TERMINAL)
Product Details
- Cat. No.
- MCA2738
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
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Description
Mouse anti Human BAX antibody, clone 2D2 recognizes an epitope within the N-terminal (NT) region of human apoptosis regulator BAX, also known as Bcl-2-like protein 4. BAX is a pro-apoptotic member of the Bcl-2 family. BAX accelerates programmed cell death by binding to and antagonizing the apoptosis repressor Bcl-2E1B 19k protein. It also induces the release of cytochrome C , activation of caspase-3 and thereby apoptosis. Defects in BAX are found in some cell lines from hematopoietic malignancies as T-cell acute lymphoblastic leukemia, Burkitt lymphoma, and plasmacytoma (Brimmell et al. 1998).Mouse anti Human BAX antibody, clone 2D2 has been successfully used for the immunoprecipitation of bovine BAX from thymus (Basañez et al. 1999).
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: African Green Monkey, Bovine, Human
- Isotype: IgG1
Handling
- Quantity: 0.1 mg
- Storage: +4ºC, -20ºC if preferred
- Buffer: Phosphate buffered saline, 0.09% Sodium Azide
Applications
- ELISA (ELISA)
- Immunofluorescence (IF)
- Immunoprecipitation (IP)
- Western Blotting (WB)