MOUSE ANTI HUMAN Bcl-10
Product Details
- Cat. No.
- MCA2750GA
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
Staining of paraffin embedded human tonsil with Mouse anti Human Bcl-10
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Description
Mouse anti Human Bcl-10 antibody, clone 151 recognizes human B-cell lymphoma/leukaemia 10 (Bcl-10), a 31kD CARD (caspase recruitment domain) containing molecule that is involved in the regulation of apoptosis. Bcl-10 was originally identified through its direct involvement in t(1;14)(p22;q32) of mucosa-associated lymphoid tissue (MALT) lymphoma. The Bcl-10 molecule is predominantly located in the cytoplasm but expression has also been reported in the nucleus of some lymphomas.Reports suggest that Bcl-10 is essential for nuclear factor (NF)-kappaB activation after lymphocyte receptor antigen stimulation and for the development of mature B-cells via ubiquitination of NEMO (Zhouet al. 2004).
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human
- Isotype: IgG1
Handling
- Quantity: 0.1 mg
- Storage: +4ºC, -20ºC if preferred
- Buffer: Phosphate buffered saline, 0.09% Sodium Azide
Applications
- ELISA (ELISA)
- Flow Cytometry (FC)
- Immunoprecipitation (IP)
- Western Blotting (WB)
