Product & ReviewsAntibodies

MOUSE ANTI HUMAN Bcl-10

Product Details

Cat. No.
MCA2750GA
Type
Primary Antibody
Clonality
Monoclonal
Host
Mouse
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Bio-Rad

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Description

Mouse anti Human Bcl-10 antibody, clone 151 recognizes human B-cell lymphoma/leukaemia 10 (Bcl-10), a 31kD CARD (caspase recruitment domain) containing molecule that is involved in the regulation of apoptosis. Bcl-10 was originally identified through its direct involvement in t(1;14)(p22;q32) of mucosa-associated lymphoid tissue (MALT) lymphoma. The Bcl-10 molecule is predominantly located in the cytoplasm but expression has also been reported in the nucleus of some lymphomas.Reports suggest that Bcl-10 is essential for nuclear factor (NF)-kappaB activation after lymphocyte receptor antigen stimulation and for the development of mature B-cells via ubiquitination of NEMO (Zhouet al. 2004).

Biological Information

  • Clonality: Monoclonal
  • Host: Mouse
  • Reactivity: Human
  • Isotype: IgG1

Handling

  • Quantity: 0.1 mg
  • Storage: +4ºC, -20ºC if preferred
  • Buffer: Phosphate buffered saline, 0.09% Sodium Azide

Applications

  • ELISA (ELISA)
  • Flow Cytometry (FC)
  • Immunoprecipitation (IP)
  • Western Blotting (WB)
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