Product & ReviewsAntibodies

MOUSE ANTI HUMAN CD155

Product Details

Cat. No.
MCA4644
Type
Primary Antibody
Clonality
Monoclonal
Host
Mouse
Buy Now
Bio-Rad

Receive your quote directly from the manufacturer.

Description

Mouse anti Human CD155 antibody, clone SKII.4 recognizes human CD155, otherwise known as poliovirus receptor (PVR). CD155 is a 397 amino acid type I transmembrane glycoprotein with a predicted molecular mass of ~45 kDa, a member of the nectin family, which acts as a mediator of cell-cell adhesion and cell migration, and is a receptor for poliovirus and cytomegalovirus. CD155 is a primate-restricted marker expressed by monocytes, macrophages, CD34+ thymocytes, endothelial and epithelial cells, and exists as both cell surface (alpha and delta) and secreted (beta and gamma) isoforms. CD155 promotes natural killer (NK) cell adhesion and NK effector functions, interacting with the NK receptors CD96 (Tactile) and CD226 (DNAM-1). CD155 forms a heterodimer with CD113 (nectin-3) which then binds to integrin alphaVbeta3.Mouse anti Human CD155 antibody, clone SKII.4 has been shown to inhibit NK cell-mediated lysis (Fuchs et al. 2004).

Biological Information

  • Clonality: Monoclonal
  • Host: Mouse
  • Reactivity: Human
  • Isotype: IgG1

Handling

  • Quantity: 0.2 mg
  • Storage: +4ºC, -20ºC if preferred
  • Buffer: Phosphate buffered saline, 0.09% Sodium Azide

Applications

  • Flow Cytometry (FC)
  • Immunofluorescence (IF)
  • Immunohistochemistry (Frozen Sections) (IHC (Fr))
Specificity rating
Sensitivity rating
Quality rating
Write your own review

Product Overview

Links