MOUSE ANTI HUMAN CD163
Product Details
- Cat. No.
- MCA1853
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
Figure A. mouse anti human CD14. Figure B. mouse anti human CD14 and mouse anti human CD163.
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Description
Mouse anti Human CD163 antibody, clone EDHu-1 recognizes the human CD163 cell surface antigen, a 130-140 kDa glycoprotein expressed by tissue macrophages. CD163 is not expressed by resting peripheral blood leucocytes but expression may be induced on monocytes by culture in dexamethasone.Clone EDHu-1 is reported to inhibit the binding of haptoglobin/hemoglobin to CD163 (Madsen et al. 2004).Truncation mutation analysis demonstrates binding of EDHu-1 occurs via the N-terminal region of CD163 containing the first three scavenger receptor, Cysteine-rich, SRCR domains the third domain being critical as, cleavage of this domain at the major cleavage site ASP-265 abrogates binding to the N-terminal fragment.
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Bovine, Guinea Pig, Human, Pig (Swine), Rhesus Monkey, Sheep (Ovine)
- Isotype: IgG1
Handling
- Quantity: 0.2 mg
- Storage: +4ºC, -20ºC if preferred
- Buffer: Phosphate buffered saline, 0.09% Sodium Azide
Applications
- ELISA (ELISA)
- Flow Cytometry (FC)
- Immunoassay (IA)
- Immunofluorescence (IF)
- Immunohistochemistry (Frozen Sections) (IHC (Fr))
