MOUSE ANTI HUMAN CD206
Product Details
- Cat. No.
- MCA2155
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
Mouse anti Humaqn CD206 antibody used for the identification of M2 macrophages
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Description
Mouse anti Human CD206 monoclonal antibody, clone 15-2 recognizes human macrophage mannose receptor 1, also known as CD206 or C-type lectin domain family 13 member D-like. CD206 is a ~175 kDa single pass type I transmembrane glycoprotein belonging to the group of pattern recognition receptors (Paveley et al. 2011). CD206 has multiple carbohydrate recognition motifs and acts as a receptor for bacteria, fungi and other pathogens (Ezekowitz et al. 1990). CD206 is predominantly expressed in tissue macrophages and dendritic cells (Engering et al. 1997) and can also be found in a subpopulation of endothelial cells (Pack et al. 2007) and sperm cells (Cardona-Maya et al. 2006). CD206 can also be detected in a soluble form in human plasma and is elevated in patients with acute sepsis (Rødgaard-Hansen et al. 2013).Mouse anti CD206, clone 15-2 has been used extensively to monitor mannose receptor modulation in macrophages treated with a wide range of cytokines and growth factors (Chang et al. 2004) and to indicate CD206 as a marker for alternative activation of macrophages (Joerink et al. 2011).
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human
- Isotype: IgG1
Handling
- Quantity: 0.2 mg
- Storage: +4ºC, -20ºC if preferred
- Buffer: Phosphate buffered saline, 0.09% Sodium Azide
Applications
- Flow Cytometry (FC)
- Immunofluorescence (IF)
- Immunohistochemistry (Frozen Sections) (IHC (Fr))
- Western Blotting (WB)
