Mouse anti Human CD261 antibody, clone DR-4-02 recognizes human death receptor 4 (DR4), also known as CD261 or TRAIL- R1. DR4 is a type I transmembrane protein of 468 amino acids, which is expressed in most human tissues including spleen, peripheral blood leucocytes, thymus and in a variety of tumour-derived cell lines. DR4 plays a role in inducing cell death. The binding of TRAIL to DR4 triggers the activation of pro-caspases 8 and 10, leading to apoptosis.
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human
- Isotype: IgG1
- Quantity: 100 TESTS/1ml
- Storage: +4ºC, -20ºC if preferred
- Buffer: Phosphate buffered saline, 0.09% Sodium Azide, 1% BSA
- Flow Cytometry (FC)
- Immunoprecipitation (IP)
