MOUSE ANTI HUMAN CD263
Product Details
- Cat. No.
- MCA2559
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
Human Granulocytes stained with Mouse anti Human CD263 (MCA2559GA)
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Description
Mouse anti Human CD263 antibody, clone 2B8 recognizes human CD263, a ~60 kDa cell surface protein, which is otherwise known as decoy receptor 1 (DcR1). CD263 is a member of the tumour necrosis factor (TNF) receptor superfamily that binds to TNF-related apoptosis inducing ligand (TRAIL). As the receptor does not possess cytoplasmic death domains it cannot induce apoptosis, but instead plays an important role in inhibiting TRAIL-induced apoptosis. CD263 is expressed in normal tissues including heart, skeletal tissues and peripheral blood neutrophils, but weakly expressed in tumour cells.The 2B8 antibody does not inhibit DcR1 (CD263) inhibitory function in TRAIL-induced apoptosis.
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human
- Isotype: IgG1
Handling
- Quantity: 0.2 mg
- Storage: +4ºC, -20ºC if preferred
- Buffer: Phosphate buffered saline, 0.09% Sodium Azide
Applications
- Flow Cytometry (FC)
- Immunoprecipitation (IP)
