MOUSE ANTI HUMAN CD274
Product Details
- Cat. No.
- MCA6132
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
Surface staining of PHA-stimulated PBMCs with Mouse anti Human CD274:RPE (MCA6132PE)
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Description
Mouse anti Human CD274 antibody, clone 29E.2A3 detects human CD274, also known as B7-H1 and PD-1L, a cell surface glycoprotein which is a member of the B7 family of co-stimulatory molecules. CD274 is expressed constitutively on macrophages and dendritic cells, and is induced on activated T cells, B cells, endothelial cells and epithelial cells in response to interferons alpha, beta and gamma.CD274 is reported to possess dual functions; inhibition of activated effector T cells and co-stimulation of naïve T cells. CD274 inhibits proliferation of activated T cells via ligation to the co-inhibitory molecule CD279 (programmed death-1; PD-1) leading to the secretion of the regulatory cytokine interleukin-10. CD274 has also been shown to co-stimulate early T cell priming and differentiation.Deregulated CD274 function has been reported in chronic viral and intracellular bacterial infection, as well as in many autoimmune diseases and cancers.
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human, Primate
- Isotype: IgG2b
Handling
- Quantity: 0.1 mg
- Storage: +4ºC DO NOT FREEZE
- Buffer: Phosphate buffered saline
Applications
- Flow Cytometry (FC)
- Functional Studies (Func)
- Immunohistochemistry (Frozen Sections) (IHC (Fr))
