MOUSE ANTI HUMAN CD279
Product Details
- Cat. No.
- MCA6133
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
Surface staining of PHA-activated human PBMCs with Mouse anti Human CD279:RPE (MCA6133PE)
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Description
Mouse anti Human CD279 antibody, clone EH12.2H7 detects CD279, a co-stimulatory molecule also known as programmed cell death-1 (PD-1).CD279 is a ~50-55 kDa membrane protein which is a member of the CD28 family, and functions as a regulator of T cell activation (Fife and Pauken, 2011). It has two specific ligands; CD274 (PD-L1) and CD273 (PD-L2), and their interaction is key in the balance between stimulatory and inhibitory signals needed for effective immune responses to microbes and self-tolerance.CD279 is a marker for germinal center-associated T cells (Dorfman et al, 2006) and is inducibly expressed by T cells, B cells, NKT cells and monocytes upon activation.
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human, Primate
- Isotype: IgG1
Handling
- Quantity: 0.1 mg
- Storage: +4ºC DO NOT FREEZE
- Buffer: Phosphate buffered saline
Applications
- Flow Cytometry (FC)
- Immunohistochemistry (Frozen Sections) (IHC (Fr))
