MOUSE ANTI HUMAN CD47
Product Details
- Cat. No.
- MCA2514
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
Figure A. Mouse anti Human CD3. Figure B. Mouse anti Human CD3 and Mouse anti Human CD47.
Receive your quote directly from the manufacturer.
Description
Mouse anti Human CD47 antibody, clone 1/1A4 recognizes human CD47, also known as integrin-associated protein, a 50kDa glycoprotein expressed on all haematopoietic cell lines, epithelial cells, endothelial cells, fibroblasts and many tumour cell lines. CD47 is involved in several cellular processes including regulation of T cell and dendritic cell activation, regulation of neutrophil (PMN) chemotaxis, caspase-independent apoptosis, and may act as a signal transducer in the regulation of cation fluxes across cell membranes. CD47 has been identified as a ligand for the inhibitory macrophage receptor known as signal regulatory protein alpha (SIRPalpha) and as a receptor for thrombospondin-1. Cross-linking of CD47 with clone 1/1A4 co-stimulates the proliferation of T cells (Waclavicek et al. 1993).
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human
- Isotype: IgG2b
Handling
- Quantity: 0.2 mg
- Storage: +4ºC, -20ºC if preferred
- Buffer: Phosphate buffered saline, 0.09% Sodium Azide
Applications
- Flow Cytometry (FC)
- Immunohistochemistry (Frozen Sections) (IHC (Fr))
- Immunoprecipitation (IP)
