MOUSE ANTI HUMAN ESTROGEN RECEPTOR BETA 1

Mouse anti Human estrogen receptor beta 1, clone PPG5/10 recognizes the estrogen receptor beta 1 (ERB1), one of several isoforms of estrogen receptor (ER) which can be used in conjunction with progesterone receptor (PR) and HER2/neu (CD340), to help determine both prognosis and the effectiveness of hormonal therapy, in breast cancer patients. Prognosis and survival rate varies greatly depending on cancer type, stage and treatment.. Mouse anti Human estrogen receptor beta 1, clone PPG5/10 is increasingly being utilized in the immunohistochemical staining of formal fixed paraffin embedded tissue, in preference to ligand binding assays, for the detection of ER/PR. ER/PR is present in approximately 75% to 80% of breast tumors, and breast cancer cells with these receptors depend on the hormones estrogen and/or progesterone to grow (Saunders, P. et al., 2002 and Nelson, A.W. et al., 2017).Mouse anti Human estrogen receptor beta 1, clone PPG5/10 can be used to demonstrate the nuclear presence of ERB1 within cells of the breast (Shaaban, A.M.et al., 2008), ovary, uterus, oviduct, testis, prostate, bladder and male reproductive ducts.BE ADVISED: Publications (Nelson, A.W. et al., 2017 and Andersson, S. et al., 2017) have queried the validity of clone PPG5/10. Please refer to the references section of this product's web page or datasheet for further information.

• Clonality: Monoclonal
• Host: Mouse
• Reactivity: Cynomolgus Monkey, Goose, Human, Llama, Marmoset, Pig (Swine), Primate, Primate, Rat, Rhesus Monkey, Sheep (Ovine), Turtle
• Isotype: IgG2a

• Quantity: 0.1 ml
• Storage: +4ºC, -20ºC if preferred
• Buffer: 0.1% Sodium Azide

• Immunofluorescence (IF)
• Immunohistochemistry (Frozen Sections) (IHC (Fr))
• Immunohistochemistry (Paraffin-Embedded Sections) (IHC (P))