MOUSE ANTI HUMAN TWEAK

Mouse anti Human TWEAK antibody, clone C06-3C8 recognizes TWEAK, a 23 kDa type II transmembrane protein belonging to the Tumour Necrosis Factor (TNF) superfamily. While TWEAK is cell surface-associated, a smaller biologically active form can also be shed into the extracellular milieu.TWEAK, expressed primarily as a soluble cytokine by infiltrating leukocytes, mediates multiple activities through its receptor FGF-inducible molecule 14 (Fn14, TNFRSF12). It is a weak inducer of apoptosis in some cell types and is involved in the induction of inflammatory cytokines (Chicheportiche et al. 1997). This cytokine also promotes proliferation and migration of endothelial cells and acts as a regulator of angiogenesis. As a result of its pro-angiogenic effects, the role of this pathway in tumor biology has also been discussed (Michaelson & Burkly, 2009).

• Clonality: Monoclonal
• Host: Mouse
• Reactivity: Human
• Isotype: IgG1

• Quantity: 0.1 mg
• Storage: +4ºC, -20ºC if preferred
• Buffer: Phosphate buffered saline, 0.09% Sodium Azide

• ELISA (ELISA)