Product & ReviewsAntibodies
MOUSE ANTI RAT CD80
Product Details
- Cat. No.
- MCA2873GA
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
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Description
Mouse anti Rat CD80, clone 3H5 specifically recognizes rat CD80, otherwise known as B7-1, a type I transmembrane glycoprotein and member of the Ig superfamily, which acts as a ligand for both CD28 and CD152 (CTLA-4), and is primarily expressed on antigen presenting cells (APCs) including dendritic cells. CD80 is a B cell activation antigen, which functions in the CD28-CD80/CD86 co-stimulatory pathway vital for T cell activation and proliferation. In contrast, the interaction of CD80 with CD152 has an inhibitory effect on T cell responses. Clone 3H5 has been shown to block the co-stimulatory activity of rat CD80.
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Rat
- Isotype: IgG1
Handling
- Quantity: 0.1 mg
- Storage: +4ºC, -20ºC if preferred
- Buffer: Phosphate buffered saline, 0.09% Sodium Azide
Applications
- Flow Cytometry (FC)
- Immunohistochemistry (Frozen Sections) (IHC (Fr))
- Immunoprecipitation (IP)