MOUSE ANTI RAT CD86
Product Details
- Cat. No.
- MCA2874
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
Immunoperoxidase staining of rat lymph node cryosection with Mouse anti Rat CD86 antibody
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Description
Mouse anti Rat CD86 antibody, clone 24F recognizes rat CD86, otherwise known as B7-2, a type I transmembrane protein and member of the Ig superfamily, which acts as a ligand for both CD28 and CD152 (CTLA-4), and is primarily expressed on antigen presenting cells (APCs) including dendritic cells, and also on germinal centre B cells and macrophages. Like CD80, CD86 is an accessory molecule which functions in the CD28-CD80/CD86 co-stimulatory pathway, vital for T cell activation, crosstalk between T and B cells, and Th2-mediated Ig production. Mouse anti Rat CD86 antibody, clone 24F has been shown to block the co-stimulatory activity of rat CD86 (Maeda et al. 1997).
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Rat
- Isotype: IgG1
Handling
- Quantity: 0.25 mg
- Storage: +4ºC, -20ºC if preferred
- Buffer: Phosphate buffered saline, 0.09% Sodium Azide
Applications
- Flow Cytometry (FC)
- Immunohistochemistry (Frozen Sections) (IHC (Fr))
- Immunoprecipitation (IP)
