Western Blot analysis of HepG2 untreated and EGF treated whole cell lysates
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Mouse anti STAT3 antibody recognizes signal transducer and activator of transcription 3, also known as DNA-binding protein APRF, acute-phase response factor and signal transducer and activator of transcription 3, when phosphorylated at serine 727. STAT3 is a member of the STAT family of transcription factors, which play a key role in numerous processes including cell differentiation, proliferation and transformation. Serine 727 is a key STAT3 phosphorylation site. Ser727 is phosphorylated by multiple kinases including mitogen-activated kinases (MAPK), mammalian target of rapamycin kinase (mTOR), cyclin-dependent kinase 5 (CDK5) and nemo-like kinase (Wakahara et al. 2012). There is an ongoing debate in the scientific literature around the impact of the phosphorylation at serine 727 (Wakahara et al. 2012). Some reports indicate that the transcriptional activity of STAT3 coincides with phosphorylation at serine 727 (Yokogami et al. 2000). Other reports show STAT3 activation independent of serine 727 (Wakahara et al. 2012). The role of serine 727 is likely dependent on the larger cellular context.
