MTHFD1 Antibody (A-8)

MTHFD1 Antibody (A-8) is a high quality monoclonal MTHFD1 antibody (also designated MTHFD1 antibody) suitable for the detection of the MTHFD1 protein of human origin. MTHFD1 Antibody (A-8) is available as both the non-conjugated anti-MTHFD1 antibody form, as well as multiple conjugated forms of anti-MTHFD1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) is a 935-amino acid, folate-dependent protein that is responsible for the consecutive interconversion of tetrahydrofolate derivatives which drive the synthesis of purine, methionine, and thymidylate. The cytosolic MRHFD1 contains three subunits, 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase, and 10-formyltetrahydrofolate synthetase, each with distinct activities. MTHFD1 functions as a homodimer consisting of two major domains, an N-terminal containing the dehydrogenase and cyclohydrolase activities and a larger synthetase domain in the C-terminus. Mutations in the MTHFD1 gene in pregnant women are associated with an increased risk of giving birth to a child with a neural tube defect, along with a possible risk of decreased embryo survival. MTHFD1 also plays a role in migraine development, since folate metabolism is involved in migraine pathophysiology, mainly in migraine with aura.

• Clonality: Monoclonal
• Host: Mouse
• Reactivity: Human

• Specificity: 4

• ELISA (ELISA)
• Immunofluorescence (IF)
• Immunohistochemistry (Paraffin-Embedded Sections) (IHC (P))
• Immunoprecipitation (IP)
• Western Blotting (WB)