Product & ReviewsAntibodies
Mucin-1 Antibody
Product Details
- Cat. No.
- 251746
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
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Description
CA15-3 (MUC-1) is a type I transmembrane protein expressed in the apical membrane of highly polarized epithelial cells. CA15-3 is also overexpressed in epithelial tumors, such as breast or ovarian cancer. CA15-3 is composed of alpha and beta subunits. The alpha subunit has cell adhesive properties, whereas the beta subunit modulates signaling in the SRK, ERK, and NF-kappa B pathways. CA15-3 is used as a serological clinical marker of breast cancer to monitor response to breast cancer treatment and disease recurrence.
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human
- Antigen: Human milk fat globule membranes.
- Clone: EMA-39
- Isotype: Mouse IgG1
- Gene: P15941
Handling
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Immunohistochemistry (IHC)